crest                

 

CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS



 

Value of Information Methods



Required Reading:

  1. Willan AR, Chen M. Value of Information Methods in Clinical Research. (Chapters 2 to 3) Download

  2. Willan AR, Eckermann S. Value of information and pricing new health care interventions. PharmacoEconomics 2012; 30(6):447-459. Download



References:

  1. Willan AR, Pinto EM. The expected value of information and optimal clinical trial design. Statistics in Medicine 2005; 24:1791-1806. Correction Statistics in Medicine 2006; 25:720.

  2. Eckermann S, Willan AR. Expected value of information and decision making in HTA. Health Economics 2007; 16:195-209.

  3. Willan AR. Clinical decision making and the expected value of information. Clinical Trials 2007; 4:279-585.

  4. Eckermann S, Willan AR. Time and EVSI wait for no patient. Value in Health 2008; 11:552-526.

  5. Eckermann S, Willan AR. The option value of delay in health technology assessment. Medical Decision Making 2008; 28:300-305.

  6. Willan AR, Kowgier ME. Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods. Clinical Trials 2008; 5:289-300.

  7. Willan AR. Optimal sample size determinations from an industry perspective based on the expected value of information. Clinical Trials 2008; 5:587-594.

  8. Eckermann S, Willan AR. Globally optimal trial design for local decision making. Health Economics 2009; 18:203-216.

  9. Willan AR, Eckermann S. Optimal clinical trial design using value of information methods with imperfect implementation. Health Economics 2010; 19:549-561.

  10. Willan AR, Goeree R, Boutis K. Value of Information methods for planning and analyzing clinical studies optimize decision making and research planning. Journal of Clinical Epidemiology 2012; 65(8):870-876.

  11. Willan AR, Eckermann S. Accounting for between-study variation in incremental net benefit in value of information methodology. Health Economics 2012; 21(10):1183–1195.

  12. Chen MH, Willan AR. Determining optimal sample sizes for multistage adaptive randomized clinical trials from an industry perspective using value of information methods. Clinical Trials (accepted for publication).


Class Notes