CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS

Longitudinal Data Analysis in Clinical Trials I

Required Reading:

1. Zeger SL, Liang KY. An overview of methods for the analysis of longitudinal data. Statistics in Medicine 1992 11: 1825-1839.
2. Laird NM, Ware JH. Random effects models for longitudinal data. Biometrics 1982; 38: 963-974.
3. Hanley JA, Negassa A, deB. Edwardes, MD, Forrester JE. Statistical analysis of correlated data using generalized estimating equations: An orientation. American Journal Epidemiology 2003; 157: 364-375.

References:

1. Raboud JM, Montaner JSG, Thorne A, Singer J, Schechter MT. Impact of missing data due to dropouts on estimates of the treatment effect in a randomized trial of antiretroviral therapy for HIV infected individuals. JAIDS Journal of Acquired Immune Deficiency Syndromes 1996; 12: 46-55.
2. Gibbons RD, Hedeker D, DuToit S. Advances in analysis of longitudinal data. Annual Rev Clin Psychol 2010; 6: 79-107.
3. Marshall JA, Scarbro S, Shetterly SM, Jones RH. Improving power with repeated measures: diet and serum lipids. American Journal of Clinical Nutrition 1998; 67: 934-939.
4. Yuan YC. Multiple imputation for missing data: concepts and new development. SAS Institute P267-25

Class Notes

Assignment