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CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS



 

Multiplicity



Required Reading:

  1. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing Journal of the Royal Statistical Society, Series B 1995; 57: 289-300.

  2. Zhang J, Quan H, Ng J, Stepanavage ME. Some statistical methods for multiple endpoints in clinical trials. Controlled Clinical Trials 1997; 18: 204-221.

  3. Johnson MF. Issues in planning interim analyses. Drug Information Journal 1990; 24: 361-370.



References:

  1. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Statistics in Medicine 1990; 9: 811-818.

  2. Wright SP. Adjusted p-values for simultaneous inference. Biometrics 1992; 48: 1005-1013.

  3. Proschan, M. A multiple comparison procedure for three- and four-armed controlled clinical trials. Statistics in Medicine 1999; 18: 787-798.

  4. Russek-Cohen E, Simon RM. Evaluating treatments when a gender by treatment interaction may exist. Statistics in Medicine 1997; 16: 455-464.

  5. Lehmacher W. et al. Procedures for two-sample comparisons with multiple endpoints controlling the experimentwise error rate. Biometrics 1991; 47: 511-521.

  6. Biopharmaceutical statistics for drug development (RM301.4 .B557 1988): Chapter 11.


Class Notes