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CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS



 

Sample Size Determinations



Required Reading:

  1. Dupont WD, Plummer WD. Power and sample size calculations. A review and computer program. Controlled Clinical Trials 1990; 11: 116-128.

  2. Wittes J. Sample size calculations for randomized controlled trials. Epidemiologic Reviews 2002; 24: 39-53.

  3. Lenth RV. Some practical guidelines for effective sample size determination. The American Statistician 2001; 55: 187-193.



References:

  1. Diggle PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data 1994; Oxford: Clarendon Press, Chapter 2.

  2. Jones B, Jarvis P, Lewis JA, Ebbutt AF. Trials to assess equivalence: the importance of rigorous methods. British Medical Journal 1996; 313: 36-39.

  3. Lancaster GA, Dodd S, Williamson PR. Design and Analysis of pilot studies: recommendations for good practise. Journal of Evaluation in Clinical Practice 2004; 10: 307-312.

Class Notes