CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS

Introduction to Survival Analysis in Clinical Trials

Required Reading:

1. Wu L, Gilbert PB. Flexible weighted log-rank tests optimal for detecting early and/or late survival differences. Biometrics 2002; 58(4): 997-1004.
2. Clark TG, Bradburn MJ, Love SB, Altman DG. Survival Analysis Part I: Basic concepts and first analyses. British Journal of Cancer 2003; 89: 232-238.
3. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data1980; New York: John Wiley & Sons: Chapter 1.

OR

4. Collett D. Modelling survival data in medical research 1994; Chapman and Hall: Chapter 2

OR

5. Cox DR, Oakes D. Analysis of survival data 1984; Chapman and Hall: Chapter 4.

Class Notes

R code for example

Example Data A

Example Data B