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CHL 5225 H -- ADVANCED STATISTICAL METHODS FOR CLINICAL TRIALS



 

Sample Size for Time to Event Analysis



Required Reading:

  1. Collett. Modelling Survival Data in Medical Research. Chapman & Hall. Chapter 10

  2. Pintilie M. Dealing with competing risks: testing covariates and calculating sample size. Statistics in Medicine 2002; 21: 3317-3324.

  3. Pintilie M. An Introduction to Competing Risks Analysis Revista Espanola De Cardiologia 2011; 64(7): 599-605.



References:

  1. Ahnn S, Anderson SF. Sample Size Determination in Complex Clinical Trials Comparing More than Two Groups for Survival Endpoints. Statistics in Medicine 1998; 17(21): 2525-2534.

  2. Hsieh FY, Lavori PW. 2000. Sample-Size Calculations for the Cox Proportional Hazards Regression Model with Nonbinary Covariates. Controlled Clinical Trials 2000; 21(6): 552-560.

  3. Jung SH, Hui S. Sample Size Calculation for Rank Tests Comparing K Survival Distributions. Lifetime Data Analysis 2002; 8(4): 361-373.

  4. Makuch RW, Simon RM. Sample-Size Requirements for Comparing Time-to-Failure among K-Treatment Groups. Journal of Chronic Diseases 1982; 35(11): 861-867.


Class Notes

R-code for